Bleeding-Related Deaths in Relation to the Duration of Dual-Antiplatelet Therapy After Coronary Stenting
Tullio Palmerini, Letizia Bacchi Reggiani, Diego Della Riva, Mattia Romanello, Fausto Feres, Alexandre Abizaid, Martine Gilard, Marie-Claude Morice, Marco Valgimigli, Myeong-Ki Hong, Byeong-Keuk Kim, Yangsoo Jang, Hyo-Soo Kim, Kyung Woo Park, Antonio Colombo, Alaide Chieffo, Jung-Min Ahn, Seung-Jung Park, Stefanie Schüpke, Adnan Kastrati, Gilles Montalescot, Philippe Gabriel Steg, Abdourahmane Diallo, Eric Vicaut, Gerard Helft, Giuseppe Biondi-Zoccai, Bo Xu, Yaling Han, Philippe Genereux, Deepak L. Bhatt and Gregg W. Stone
Estimates of Risk in the Intention-to-Treat Population for Bleeding-Related Deaths and Deaths Not Related to Bleeding Between Shorter and Longer Dual-Antiplatelet Therapy
Short dual-antiplatelet therapy (DAPT) was associated with significantly lower rates of bleeding-related deaths compared with prolonged DAPT (A), whereas no significant difference was apparent in deaths not related to bleeding between the 2 groups (B). D+L = DerSimonian and Laird; DES-LATE = Optimal Duration of Clopidogrel Therapy With DES to Reduce Late Coronary Arterial Thrombotic Event; EXCELLENT = Efficacy of Xience/Promus Versus Cypher to Reduce Late Loss After Stenting; I LOVE IT = Evaluate Safety and Effectiveness of the Tivoli DES and the Firebird DES for Treatment of Coronary Revascularization; I-V = inverse variance; ISAR-SAFE = Intracoronary Stenting and Antithrombotic Regimen: Safety and Efficacy of 6 Months Dual Antiplatelet Therapy After Drug-Eluting Stenting; ITALIC = Is There a Life for DES After Discontinuation of Clopidogrel; OPTIDUAL = Optimal Dual Antiplatelet Therapy; OPTIMIZE = Optimized Duration of Clopidogrel Therapy Following Treatment With the Zotarolimus-Eluting Stent in Real-World Clinical Practice; PRODIGY = The Prolonging Dual Antiplatelet Treatment After Grading Stent-Induced Intimal Hyperplasia Study; RESET = Real Safety and Efficacy of a 3-Month Dual Antiplatelet Therapy Following E-ZES Implantation; SECURITY = Second Generation Drug-Eluting Stents Implantation Followed by Six Versus Twelve-Month - Dual Antiplatelet Therapy.